Current Issue : July-September Volume : 2017 Issue Number : 3 Articles : 5 Articles
Transdermal drug delivery system having many advantages over the oral and other route of administration. It prevent hepatic first pass metabolism. This drug delivery system increases more patient compliance. It is a targeted and controlled drug delivery system. Some physiochemical and biological factors can affect the bioavailability of transdermal medicament. Nowadays, various recent technologies arises that importantly contributed and full fill this system. The present review article explores the overall study on transdermal drug delivery system (TDDS) which leads to novel drug delivery system (NDDS)....
Asthma is a chronic inflammatory disorder of the airways characterized by an obstruction of airflow, which may be completely or partially reversed with or without specific therapy. Asthma attacks can be related to changes in atmospheric temperature, barometric pressure and the quality of air. In some patients, fungi, bacteria or parasites may be responsible for asthma condition. Asthma is having the subtype such as allergic and nonallergic. Salbutamol sulphate is widely used as bronchodilator to manage asthma and other chronic obstructive airway disease. More recently, orally disintegration films (or strips) have come to light. As the mucoadhesive buccal films (or strips) are small in size and thickness, it has improved patient compliance, compared to tablets. The natural and synthetic polymers are used in the formulation of fast dissolving oral strip and were prepared by solvent casting method. The strips which were prepared using combination of polymers (HPMC E-15 with maltodextrin) showed excellent dissolution profile compared to strips prepared with individual polymers and mannitol used as a solubiliser. It was observed from the results that, A-3 and C-3 formulations showed maximum dissolution rate of about 99% in 15 min, thus it was concluded that designed films showed rapid disintegration and immediate drug release....
The present study deals with the potential of solid lipid nanoparticles intended for oral use in improving oral bioavailability of ketoprofen. The objective of the study was to develop and optimise the ketoprofen loaded solid lipid nanoparticles using solvent injection technique. The independent variables drug/lipid (Glyceryl monostearate) ratio and concentration of emulsifier (Poloxamer 407) were analysed using central composite design to study effect on response variables such as particle size, percent entrapment efficiency and percent cumulative drug release. In order to select the optimized formula nanoparticles were subjected to characterizations studies. The optimized batch showed average particle size of 158.8 nm with percent drug entrapment and cumulative drug release of 65.97% and 66.63% respectively. Optimised batch best fitted in korsmeyer-Peppas model of drug release kinetics. The optimised batch then filled in enteric coated capsule to facilitate complete dissolution of drug and to prevent the release of drug in stomach and associated unwanted side effects in gastrointestinal tract....
Generally oral drug delivery systems do distribute the drug with no exacting release pattern and reach the targeted system with less control effective concentration subsequently random plasma concentration. To overcome this difficulty a lot of study and improvement had done, which has involved into NDDS i.e. novel drug delivery system. It’s a huge system dealing with different release pattern like matrix, diffusion, osmotic floating liposome, nano particles, microsphere etc. These days aged as well as innovative disease treatments utilize presently developed systems for its avoidance and heal which includes NDDS which is beneficiary for patients. In NDDS, among all, osmotic drug delivery system is presently trendy in market because of its some qualities over other delivery systems. In this review article collection of old to latest technologies of osmotic delivery systems has been incorporated. Osmotic system is based on osmosis and osmotic pressure which is driving force for the solvent to pass through semi permeable membrane until equilibrium occur between the two compartments i.e. internal and external. It mostly consists of three things-a semi permeable membrane, a core and a delivery orifice....
Topical therapy is a most suitable choice for the treatment of the skin infections. Topical therapy for skin infection is advantageous because the drugs are targeting to the site of infection and reduces the risk of systemic side effects. The effectiveness of that treatment is mainly depends on the permeation of drugs through the targeting layer of skin. The skin is composed of three layers: the epidermis, the dermis and subcutaneous tissue. The skin is the largest organ of the body, accounting for about 15% of the total adult body weight. The stratum corneum of the skin acts as a principle barrier to the permeation of topically applied drugs. There are three ways in which a drug molecule can cross the intact stratum corneum: via skin appendages, intercellular lipid domains and transcellular route. This review article mainly focuses on the role and functions of skin for topical drug delivery used in the treatment of various skin infections and anatomy and physiology of the skin. The present study deals with the study of drug penetration across the skin and its kinetics....
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